Skype has been popular not only as a social video chat platform but as a communications platform for small and medium enterprises (SME). If any major changes are brought about by MS it is they who would be most affected.
Whatever the future holds for Skype users, it is clear that an era has come to an end. Microsoft would have to demonstrate that they are capable of charting a new era while retaining the confidence of the huge bank of Skype users. Any loss of confidence among Skype's customers would see newcomers cash-in on a market that for them would be like manna from heaven.
Read what ZDNet has to say: Microsoft buys Skype, so what happens next?